Cholera is a kind of potent intestinal infectious diseases caused by Vibrio cholerae, The World Health Organization (WHO) considered cholera, bubonic plague, and yellow fever as the three kind of infectious diseases that must implement the international hygienic quarantine. And it is regarded as the "the armor class" infectious disease in the legal management in China. As the kind of ancient infectious disease, cholera has had 7 times’ population over the world since the beginning of the 19^th century, without a time did not calamity China. In wars against cholera, human beings recognized the disease germ, developed the vaccine, and formulated the effective prevention measures.